9/2/2023 0 Comments Simon med arrowheadAlthough MS is a disease that predominantly affects white matter, lesions can and do occur in gray matter and are better detected on FLAIR imaging. The abnormalities of the corpus callosum, U-fibers, and optic nerves, however, may allow for the differentiation of MS from cerebrovascular disease. The focal demyelinating lesions located along the lateral borders of the corpus callosum are best depicted by sagittal fluid-attenuated inversion recovery (FLAIR) imaging ( Figs 2 and and3). 3 In addition to the periventricular region, the corpus callosum, subcortical region, brain stem, U-fibers, optic nerves, and visual pathway are also regions where lesions are frequently located. Histopathologically, such perivascular inflammation has been thought to play a primary role in the disruption of the blood-brain barrier (BBB), in myelin breakdown, and in the formation of new lesions. 1 At the initial stage, the lesions are typically thin and appear to be linear (Dawson’s fingers), which is probably associated with the inflammatory changes around the long axis of the medullary vein that create the dilated perivenular space 2 ( Fig 1). Although MS lesion plaques can be found throughout the brain, they have a predilection for periventricular white matter and tend to have an ovoid configuration with the major axes perpendicular to the ventricular surface. Today, MR imaging is the most important paraclinical tool for MS, and MR imaging–derived measures have been established as standard outcome markers to monitor the treatment response in various MS clinical trials.Ĭonventional MR scanning offers the most sensitive way to detect MS lesions and their changes and plays a dominant role in ruling in or ruling out a diagnosis of MS. With the advent of newer quantitative MR techniques-including volumetric MR imaging, magnetization transfer imaging (MTI), diffusion tensor imaging (DTI), and proton MR ( 1H-MR) spectroscopy-our ability to detect and characterize the disease burden, including occult microscopic disease invisible when using conventional MR techniques, has largely improved. Since then, MR imaging has become a routine clinical examination in MS and is used to help the diagnosis and track the natural course of the disease. The high conspicuity abnormal signal intensities of MS lesions seen on MR imaging provided the best view yet of tissue injury, lesion activity, and disease accumulation compared with all other imaging modalities, including CT. The first MR images of MS were produced in the early 1980s, when MR was introduced into hospitals. Only was told they know there are problems with scheduling and there's nothing they can do about it.Multiple sclerosis (MS) is considered an inflammatory autoimmune neurologic disease that is characterized by pathologic changes, including demyelination and axonal injury. Now I have to request to leave early from work another day and arrange another ride. When questioned, was told it really is with contrast. The rescheduled appointment was made without contrast. The appointment was rescheduled and was given a sheet with the new appointment information. When asked why it was scheduled at the wrong time and why I was told that the appointment had not been canceled, was told oh yeah there's lots of problems with scheduling. Went to the appointment only to be told it had to be rescheduled because it was scheduled at the wrong time. Called the number that was left in the message and was told the appointment was still set. An hour before the appointment, received a message saying it had to be rescheduled because it was scheduled for a non-contrast time. Had an appointment for an MRI with contrast. Giving one star because zero stars is not an option.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |